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Wikipedia - Oxaprozin

Oxaprozin
Systematic (IUPAC) name
3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
Identifiers
CAS number 21256-18-8
ATC code M01AE12
PubChem CID 4614
DrugBank APRD00030
Chemical data
Formula C18H15NO3 
Mol. mass 293.317 g/mol
Pharmacokinetic data
Bioavailability 95%
Protein binding 99%
Metabolism Liver—65% oxidation and 35% glucuronic acid conjugation. 5% are active phenolic metabolites.
Half-life 54.9 hours
Therapeutic considerations
Pregnancy cat. C
Legal status
Routes Oral
 YesY(what is this?)  (verify)

Oxaprozin, also known as Oxaprozinum, (sold under the names: Daypro or Duraprox) is a non-steroidal anti-inflammatory drug (NSAID),[1] used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative. It is available in 600 mg tablets. Normal adult dosage is 1200 mg daily, not to exceed 1800 mg per day. Safety and efficacy has been established in children over 6 years with juvenile rheumatoid arthritis only, and there is an increased risk of adverse reactions in the elderly population.

[edit] References

  1. ^ Greenblatt DJ, Matlis R, Scavone JM, Blyden GT, Harmatz JS, Shader RI (March 1985). "Oxaprozin pharmacokinetics in the elderly". British journal of clinical pharmacology 19 (3): 373–8. PMID 3986088. 
v • d • e
Non-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)
Salicylates
Arylalkanoic acids
2-Arylpropionic acids
(profens)
N-Arylanthranilic acids
(fenamic acids)
Pyrazolidine derivatives
Oxicams
COX-2 inhibitors
Sulfonanilides
Topically used products
COX-inhibiting nitric oxide donators
Others
Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.
v • d • e
Anti-inflammatory products (M01A)
Pyrazolidine/Butylpyrazolidines
Acetic acid derivatives
and related substances
Oxicams
Propionic acid derivatives
Fenamates
Coxibs
Other

M: MUS, DF+DRCT

anat (h/n,u,t/d/p,l)/phys/hist

noco(m,s,c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)
Stub icon This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
Retrieved from "http://en.wikipedia.org/wiki/Oxaprozin"

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Oxaprozin".

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